Carolyn S Calfee Selected Research

Proteins (Proteins, Gene)

2/2024	Biological Effects of Corticosteroids on Pneumococcal Pneumonia in Mice and Humans.
2/2024	Host-Microbe Multiomic Profiling Reveals Age-Dependent COVID-19 Immunopathology.
1/2024	Identification of a hyperinflammatory sepsis phenotype using protein biomarker and clinical data in the ProCESS randomized trial.
1/2024	Novel subtypes of severe COVID-19 respiratory failure based on biological heterogeneity: a secondary analysis of a randomized controlled trial.
1/2023	Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS.
1/2023	Aerosolized nicotine from e-cigarettes alters gene expression, increases lung protein permeability, and impairs viral clearance in murine influenza infection.
3/2022	Towards a biological definition of ARDS: are treatable traits the solution?
1/2022	Single Nucleotide Variant in FAS Associates With Organ Failure and Soluble Fas Cell Surface Death Receptor in Critical Illness.
1/2019	Early Plasma Matrix Metalloproteinase Profiles. A Novel Pathway in Pediatric Acute Respiratory Distress Syndrome.
1/2017	Higher mini-BAL total protein concentration in early ARDS predicts faster resolution of lung injury measured by more ventilator-free days.

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Carolyn S Calfee Research Topics

Disease

70	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 01/2024 - 03/2007
42	Sepsis (Septicemia) 01/2024 - 04/2009
34	Acute Lung Injury 12/2023 - 03/2007
31	COVID-19 04/2024 - 01/2020
30	Critical Illness (Critically Ill) 02/2024 - 06/2010
28	Inflammation (Inflammations) 04/2024 - 07/2007
25	Lung Injury 02/2024 - 03/2007
20	Wounds and Injuries (Trauma) 03/2024 - 10/2007
13	Pulmonary Edema 02/2024 - 06/2005
9	Hypoxia (Hypoxemia) 02/2024 - 04/2015
8	Pneumonia (Pneumonitis) 02/2024 - 06/2012
8	Infections 01/2023 - 02/2012
7	Acute Kidney Injury (Acute Renal Failure) 12/2020 - 01/2009
6	Shock 03/2024 - 12/2011
6	Septic Shock (Toxic Shock Syndrome) 01/2024 - 06/2010
6	Respiratory Insufficiency (Respiratory Failure) 12/2022 - 06/2005
6	Edema (Dropsy) 12/2020 - 08/2007
5	Primary Graft Dysfunction 09/2023 - 07/2007
5	Lung Diseases (Lung Disease) 12/2022 - 06/2005
5	Necrosis 01/2022 - 05/2017
4	Neoplasms (Cancer) 01/2022 - 05/2017
4	Systemic Inflammatory Response Syndrome (Sepsis Syndrome) 01/2021 - 04/2009
3	Bacterial Pneumonia 02/2024 - 01/2018
3	Viral Pneumonia 01/2023 - 01/2021
3	Asthma (Bronchial Asthma) 01/2022 - 01/2017
2	Virus Diseases (Viral Diseases) 01/2023 - 01/2022
2	Disease Progression 01/2022 - 10/2021
2	Cytokine Release Syndrome 01/2021 - 12/2020
2	Alcoholism (Alcohol Abuse) 01/2020 - 12/2014

Drug/Important Bio-Agent (IBA)

55	Biomarkers (Surrogate Marker)IBA 02/2024 - 08/2007
12	Proteins (Proteins, Gene)FDA Link 02/2024 - 06/2009
12	Interleukin-6 (Interleukin 6)IBA 02/2024 - 10/2007
11	SmokeIBA 01/2022 - 01/2011
10	CytokinesIBA 02/2024 - 08/2007
10	Oxygen (Dioxygen)IBA 01/2024 - 04/2009
9	Angiopoietin-2IBA 01/2023 - 05/2011
8	Interleukin-8 (Interleukin 8)IBA 01/2022 - 06/2010
8	von Willebrand FactorIBA 01/2019 - 10/2007
7	Simvastatin (Zocor)FDA LinkGeneric 12/2023 - 01/2014
7	ThrombomodulinIBA 01/2019 - 07/2010
6	Anti-Bacterial Agents (Antibiotics)IBA 02/2024 - 01/2018
6	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 12/2023 - 11/2018
6	InterferonsIBA 12/2022 - 01/2020
6	RNA (Ribonucleic Acid)IBA 11/2022 - 06/2015
5	ChemokinesIBA 04/2024 - 01/2018
5	Protein CIBA 11/2023 - 07/2010
5	Receptor for Advanced Glycation End ProductsIBA 09/2018 - 06/2010
4	Dexamethasone (Maxidex)FDA LinkGeneric 02/2024 - 01/2021
4	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2024 - 01/2020
4	Nicotine FDA Link 01/2023 - 01/2011
4	CreatinineIBA 09/2022 - 01/2014
4	InterleukinsIBA 01/2022 - 01/2020
4	Bicarbonates (Hydrogen Carbonate)IBA 06/2021 - 08/2014
3	GlucocorticoidsIBA 02/2024 - 08/2010
3	Blood Proteins (Serum Proteins)IBA 01/2024 - 06/2009
3	Interleukin-18 (Interleukin 18)IBA 12/2023 - 05/2017
3	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 12/2023 - 09/2022
3	Prostaglandins DIBA 09/2023 - 04/2016
3	OzoneIBA 01/2023 - 05/2016
3	Air Pollutants (Pollutants, Air)IBA 01/2023 - 01/2019
3	AerosolsIBA 01/2023 - 12/2020
3	AutoantibodiesIBA 12/2022 - 03/2021
3	Interferon Type IIBA 12/2022 - 03/2021
3	DNA (Deoxyribonucleic Acid)IBA 11/2022 - 01/2020
3	Crystalloid SolutionsIBA 01/2022 - 04/2015
3	AntigensIBA 01/2022 - 10/2007
3	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 01/2021 - 04/2009
3	LipopolysaccharidesIBA 01/2021 - 12/2016
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 12/2019 - 10/2007
3	4- (methylnitrosamino)- 1- (3- pyridyl)- 1- butan- 1- olIBA 09/2015 - 01/2011
3	Tobacco Smoke Pollution (Passive Smoking)IBA 09/2014 - 01/2011
3	Pulmonary Surfactant-Associated Protein D (Surfactant Protein D)IBA 06/2014 - 10/2007
2	VaccinesIBA 04/2024 - 02/2024
2	InflammasomesIBA 02/2024 - 12/2023
2	LipidsIBA 01/2024 - 08/2021
2	Vasopressins (Vasopressin)IBA 11/2023 - 01/2019
2	AntibodiesIBA 12/2022 - 03/2021
2	Rosuvastatin Calcium (Crestor)FDA Link 01/2022 - 11/2018
2	Acetates (Acetic Acid Esters)FDA Link 01/2022 - 12/2020
2	Vitamin E FDA LinkGeneric 01/2022 - 12/2020
2	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2020
2	EndotoxinsIBA 01/2022 - 09/2017
2	EpitopesIBA 09/2021 - 03/2021
2	Glycoproteins (Glycoprotein)IBA 01/2021 - 01/2021
2	olfactomedinIBA 01/2021 - 06/2015
2	Toll-Like Receptors (Toll-Like Receptor)IBA 11/2020 - 05/2020
2	Indicators and Reagents (Reagents)IBA 09/2019 - 08/2013
2	Matrix Metalloproteinases (MMPs)IBA 01/2019 - 01/2018

Therapy/Procedure

32	Therapeutics 03/2024 - 03/2007
11	Precision Medicine 09/2023 - 01/2016
10	Resuscitation 01/2024 - 02/2014
10	Positive-Pressure Respiration (Positive End-Expiratory Pressure) 01/2024 - 06/2005
10	Mechanical Ventilators (Ventilator) 01/2017 - 03/2007
9	Critical Care (Surgical Intensive Care) 01/2022 - 08/2010
6	Artificial Respiration (Mechanical Ventilation) 01/2024 - 07/2007
6	Lung Transplantation 09/2023 - 07/2007
4	Extracorporeal Membrane Oxygenation 01/2022 - 08/2010
3	Immunomodulation 01/2024 - 11/2018
3	Drug Therapy (Chemotherapy) 11/2023 - 01/2015
2	Catheters 10/2020 - 03/2007